By Steven B. Karch MD FFFLM
Extracted from the Drug Abuse guide, 2d variation, to offer you simply the knowledge you wish at a reasonable cost. dependancy and the scientific issues of Drug Abuse explores the physiological and mental phenomenon of dependancy together with the character of dependence, the dependence power of gear, and the significance of motivation. Contributions study the perform of alternative prescribing and element the speedy and long-term merits in their use in upkeep or managed withdrawal from opioids, stimulants, and benzodiazepines. It considers using methadone, buprenorphine, adrenergic agonists, and naltrexone for cleansing. Practitioners will enjoy the specialist guide at the administration of universal comorbidities, together with analysis and pharmaceutical therapy of mental problems. additional info covers the physiological results of every drug and the emergency administration of a number of drug comparable issues comparable to psychosis, seizures, stroke, hyperthermia, and cardiac quandary. With 29 tables and figures, professional information and huge references, this is often an critical publication for an individual within the box of dependancy or emergency drugs.
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Additional resources for Addiction and the Medical Complications of Drug Abuse
Drug Alcohol Abuse, 17, 137, 1991. 22. , 31, 19, 1992. 23. , Outpatient treatment of crack cocaine smoking with flupenthixol decanoate, Arch. Gen. Psychiatry, 46, 322, 1989. 24. , 39, 173, 1995. 25. , Pharmacological treatment of cocaine dependence: a systematic review, Arch. Gen. Psychiatry, 49, 900, 1992. 26. , Pharmacotherapy for cocaine abusing methadone maintained patients using amantadine and despiramine, Arch. Gen. Psychiatry, 49, 894, 1992. D. K. 1 OPIOID-SPECIFIC PRESCRIBING Antagonists have zero efficacy and as such are very effective blockers of agonists.
Agonist and antagonist properties of buprenorphine, Br. J. , 60, 537, 1977. 8. , Alternate day dosing during buprenorphine treatment of opioid dependence, Br. J. , 60, 537, 1994. 9. , Sublingual versus subcutaneous buprenorphine in opiate abusers, Clin. Pharmacol. , 45, 513, 1989. fm Page 21 Friday, August 31, 2007 10:03 AM SUBSTITUTE PRESCRIBING: BUPRENORPHINE MAINTENANCE PRESCRIBING 21 10. , The use of benzodiazepines among drug addicts, Br. J. , 82, 511, 1987. 11. , Ed. Oxford: Oxford Medical Publications, 1993, 9.
Typically these agents are used to reduce cravings associated with the cessation of stimulant use. Replacement prescribing is addressed in detail in Chapter 5. 3 BENZODIAZEPINE SPECIFIC Little attention has thus far been paid to the extent to which benzodiazepines are abused primarily as the drug of choice. 16 However, there appear to be a number of features that indicate benzodiazepine abuse: two key factors appear to be supra therapeutic dosage to extremely high levels and intermittent binge usage.