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By F. Spreafico, A. Mantovani, R. Giavazzi, G. Conti, A. Anaclerio (auth.), Prof. G. Mathé, Dr. G. Bonadonna, Prof. S. Salmon (eds.)

Transplantation of syngeneic (donor is a monozygous dual) or allogeneic (donor is an HLA-identical sibling) marrow offers the chance for competitive antileukemic remedy with out regard to marrow toxicity. until eventually 1975, marrow transplantation used to be conducted in simple terms after failure of all different treatment. for this reason, so much sufferers have been in complex relapse. Six of sixteen recipients of syngeneic marrow and thirteen of a hundred recipients of allogeneic marrow are nonetheless in remission after five. 5-10 years [3, 7]. An actuarial survival curve of the 1st a hundred sufferers grafted in Seattle after conditioning with cyclophos­ phamide (60 mg/kg on each one of two successive days) and overall physique irradiation (1,000 rad) confirmed 3 classes of curiosity: (1) the 1st four months confirmed a quick lack of sufferers linked to complex sickness, graft-versus-host disorder, infections (in specific interstitial pneumonias), and recurrent leukemia; (2) from four months to two years, the curve confirmed a far slower price of decline attributable essentially to recurrent leukemia; and (3) from 2-10 years, the curve was once nearly flat with a negligible lack of sufferers and no recurrent leukemia. This flat section of the curve corresponded to thirteen% of the sufferers and shows a powerful likelihood that most of those survivors are cured in their sickness [8]. makes an attempt at decreasing the prevalence of leukemic relapse after transplantation have been made by way of a few marrow transplant teams via further chemotherapy.

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Alternative Approaches Radioimmunodetection On the basis of success in experimental and xenograft systems, Goldenberg et al. [4] have employed methods of radioimmunodetection to localise various human tumours. Using xenogeneic anti-CEA labelled with radioactive iodine, they have demonstrated by scanning techniques that this approach can result in the successful localisation of 20 A. M. Neville both primary and metastatic tumours of the colon, rectum, uterus, ovary and breast. Moreover, radioimmunodetection was successful when other physical diagnostic methods did not locate the various lesions [4].

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In: Mathe G, Seligmann M, Tubiana M (eds) Lymphoid neoplasias II: Clinical and therapeutic aspects. Springer, Berlin Heidelberg New York, pp 88-107 12. Misset JL, de Vassal F, Jasmin C, Mathe G (to be published) Neuroprophylaxis in acute lymphoblastic leukemia. Correlation of neurological risk and efficacy of prevention with other prognostic factors. Eur J Cancer 13. Schaison G, Harousseau JL, Jacquillat C, Weil M, Bernard J (1979) Phase I treatment protocol for children with increased risk acute lymphocytic leukemia (IRALL).

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