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By H. Arnouk

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The vaccine was well tolerated with mild to moderate fever and tumor pain as the only adverse events observed. , 2006). Of interest, the dendritic cell hybrid vaccine induced cytotoxic T cells reactive with mucin1 tumor-associated antigen—these results need to be further confirmed in larger, randomized trials. Tumor-associated antigens can also be applied to the surface of cell-sized microspheres and then used as an immunogen. , 2002). The vaccine was given alone, in combination with cyclophosphamide, or in combination with cyclophosphamide and interleukin 2.

All studies have shown that MVA-5T4 has been safe and well-tolerated, resulting only in minor flu-like symptoms and mild reactions at the injection site. Researchers are studying the use of MVA-5T4 on metastasized cancers that have proved unresponsive to conventional systemic cytotoxic chemotherapy. MVA-5T4 has been assessed in conjunction with both high-dose and low-dose interleukin 2 therapy. , 2009). The results attributed a large number of adverse events to high-dose interleukin 2, but only two events (grade I fevers) to MVA-5T4, indicating that the regimen is safe and well tolerated in this population of patients.

They offer immunogenic response with a low toxicity profile, making them attractive options for patients with advanced stages of cancer. In renal cell carcinoma, heat shock protein-based vaccines have demonstrated effectiveness in earlier stage renal cell carcinoma patients, but manufacturing the vaccine is timeconsuming. MVA-5T4 has high potential as a viable vaccine therapy for metastatic renal cell carcinoma, and it is well tolerated in combination with other therapies. However, more information about tumor-associated antigens for renal cell carcinoma is needed before taking the next step forward into making viral-based vaccine therapy a viable option.

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